Palladium-Catalyzed Acylation Reactions: A One-Pot Diversified Synthesis of Phthalazines, Phthalazinones and Benzoxazinones

Basuli, Suchand and G, Satyanarayana (2018) Palladium-Catalyzed Acylation Reactions: A One-Pot Diversified Synthesis of Phthalazines, Phthalazinones and Benzoxazinones. European Journal of Organic Chemistry, 2018 (19). pp. 2233-2246. ISSN 1434-193X

[img] Text
European Journal of Organic Chemistry_2018_19_2233-2246_2018.docx - Accepted Version

Download (712kB)

Abstract

A sequential one‐pot strategy for the diversified synthesis of phthalazines, phthalazinones and benzoxazinones was presented. This strategy proceeds through [Pd]‐catalyzed acylation and nucleophilic cyclocondensation with dinucleophilic reagents. This process was based on direct coupling with simple bench‐top aldehydes without the assistance of directing group and without activating the carbonyl group. The process is highly advantageous because it employs simple nitrogen‐based nucleophiles, and non‐toxic and readily accessible aldehydes as the carbonyl source. Most importantly, the strategy was applied to the one‐pot synthesis of PDE‐4 inhibitor.

[error in script]
IITH Creators:
IITH CreatorsORCiD
G, SatyanarayanaUNSPECIFIED
Item Type: Article
Subjects: Chemistry
Divisions: Department of Chemistry
Depositing User: Team Library
Date Deposited: 02 Aug 2018 06:41
Last Modified: 02 Aug 2018 06:44
URI: http://raiith.iith.ac.in/id/eprint/4347
Publisher URL: http://doi.org/10.1002/ejoc.201800159
OA policy: http://www.sherpa.ac.uk/romeo/issn/1434-193X/
Related URLs:

Actions (login required)

View Item View Item
Statistics for RAIITH ePrint 4347 Statistics for this ePrint Item