Mutational Analysis and Evaluation of Inhibitors of HIV-1 Integrase – Human LEDGF/p75 Interaction

George, A and Raghavendra, N K (2018) Mutational Analysis and Evaluation of Inhibitors of HIV-1 Integrase – Human LEDGF/p75 Interaction. PhD thesis, Indian Institute of Technology, Hyderabad.

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Abstract

The present work focuses on gaining deeper understanding into the interaction interface of the HIV-1 protein integrase with the human protein LEDGF/p75 by designing point mutations in the interface residues and checking its ability to form stable complex. The interaction interface also qualify as a potential drug target site. The study also includes screening of small molecules for their potential to disrupt the integrase and LEDGF/p75 interaction and thereby inhibit HIV-1 replication. The thesis has been organized into three chapters.

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IITH Creators:
IITH CreatorsORCiD
Raghavendra, N Khttp://orcid.org/0000-0003-2220-1148
Item Type: Thesis (PhD)
Subjects: Biomedical Engineering
Divisions: Department of Biomedical Engineering
Depositing User: Team Library
Date Deposited: 18 Jun 2018 10:15
Last Modified: 18 Jun 2018 10:15
URI: http://raiith.iith.ac.in/id/eprint/4038
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