Coated platelets introduce significant delay in onset of peak thrombin production: theoretical predictions

M, Susree and Panteleev, Mikhail A and Mohan, Anand (2018) Coated platelets introduce significant delay in onset of peak thrombin production: theoretical predictions. Journal of Theoretical Biology. ISSN 0022-5193 (In Press)

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Abstract

Platelets play a crucial role in the initiation, progress, termination as well as regulation of blood coagulation. Recent studies have confirmed that not all but only a small percentage of thrombin-activated platelets (“coated” platelets) exhibit procoagulant properties (namely the expression of phosphatidylserine binding sites) required for the acceleration and progress of coagulation. A mechanistic model is developed for in vitro coagulation whose key features are distinct equations for coated platelets, thrombin dose-dependence for coated platelets, and competitive binding of coagulation factors to platelet membrane. Model predictions show significant delay in the onset of peak Va production, and peak thrombin production when dose-dependence is incorporated instead of a fixed theoretical maximum percentage of coated platelets. Further, peak thrombin concentration is significantly overestimated when either fractional presence of coated platelets is ignored (by 299.4%) or when dose-dependence on thrombin is ignored (by 24.7%).

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IITH Creators:
IITH CreatorsORCiD
Mohan, Anandhttps://orcid.org/0000-0001-7191-4991
Item Type: Article
Uncontrolled Keywords: coagulation; Coated platelets; Dose-dependence; Mechanistic model; thrombin
Subjects: Chemical Engineering
Divisions: Department of Chemical Engineering
Depositing User: Team Library
Date Deposited: 22 May 2018 10:30
Last Modified: 22 May 2018 10:30
URI: http://raiith.iith.ac.in/id/eprint/3947
Publisher URL: http://doi.org/10.1016/j.jtbi.2018.05.021
OA policy: http://www.sherpa.ac.uk/romeo/issn/0022-5193/
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