Importance of Initial Concentration of Factor VIII in a Mechanistic Model of In Vitro Coagulation

Susree, Modepalli and Mohan, Anand (2018) Importance of Initial Concentration of Factor VIII in a Mechanistic Model of In Vitro Coagulation. Acta Biotheoretica. pp. 1-12. ISSN 0001-5342

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Abstract

This computational study generates a hypothesis for the coagulation protein whose initial concentration greatly influences the course of coagulation. Many clinical malignancies of blood coagulation arise due to abnormal initial concentrations of coagulation factors. Sensitivity analysis of mechanistic models of blood coagulation is a convenient method to assess the effect of such abnormalities. Accordingly, the study presents sensitivity analysis, with respect to initial concentrations, of a recently developed mechanistic model of blood coagulation. Both the model and parameters to which model sensitivity is being analyzed provide newer insights into blood coagulation: the model incorporates distinct equations for plasma-phase and platelet membrane-bound species, and sensitivity to initial concentrations is a new dimension in sensitivity analysis. The results show that model predictions are most uncertain with respect to changes in initial concentration of factor VIII, and this hypothesis is supported by results from other models developed independently.

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IITH Creators:
IITH CreatorsORCiD
Mohan, Anandhttps://orcid.org/0000-0001-7191-4991
Item Type: Article
Additional Information: Scopus Index, web of science Index
Uncontrolled Keywords: Coagulation Factor VIII Initial concentration Mechanistic model Sensitivity analysis
Subjects: Chemical Engineering
Divisions: Department of Chemical Engineering
Depositing User: Team Library
Date Deposited: 21 May 2018 07:12
Last Modified: 25 Sep 2019 05:48
URI: http://raiith.iith.ac.in/id/eprint/3937
Publisher URL: http://doi.org/10.1007/s10441-018-9329-8
OA policy: http://www.sherpa.ac.uk/romeo/issn/0001-5342/
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