Palladium Catalyzed Direct Acylation of Iodo-acetanilides/Iodo-phenyl Acetates: Domino One-pot Synthesis of 2-Quinolinones

Basuli, Suchand and G, Satyanarayana (2017) Palladium Catalyzed Direct Acylation of Iodo-acetanilides/Iodo-phenyl Acetates: Domino One-pot Synthesis of 2-Quinolinones. European Journal of Organic Chemistry, 2018 (8). pp. 957-970. ISSN 1434-193X

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Abstract

[Pd]-catalyzed direct acylation of iodoacetanilides/iodophenyl acetates with aldehydes, was presented. Simple bench-top aldehydes were used as the non-toxic acylating agents. This protocol comprises direct coupling with aldehydes without activating the carbonyl group and without the directing group assistance. The strategy was applied to a domino one-pot synthesis of 2-quinolinones via acylation and intramolecular aldol condensation. Significantly, the strategy was extended to the domino one-pot synthesis of drugs and bioactive compounds.

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IITH Creators:
IITH CreatorsORCiD
G, SatyanarayanaUNSPECIFIED
Item Type: Article
Uncontrolled Keywords: One-pot reaction, Acylation, Quinolinones, HBV-inhibitor and Tipifarnib
Subjects: Chemistry > Organic chemistry
Divisions: Department of Chemistry
Depositing User: Team Library
Date Deposited: 25 Oct 2017 04:36
Last Modified: 02 Aug 2018 06:37
URI: http://raiith.iith.ac.in/id/eprint/3632
Publisher URL: https://doi.org/10.1002/ejoc.201701250
OA policy: http://www.sherpa.ac.uk/romeo/issn/1434-193X/
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