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Sei-Kyoung Park, Joo Y. Hong, Fatih Arslan, Vydehi Kanneganti, Basant Patel, Alex Tietsort, Elizabeth M. H. Tank, Xingli Li, Sami J. Barmada, Susan W. Liebman
Overexpression of the essential Sis1 chaperone reduces TDP-43 effects on toxicity and proteolysis
www.plosgenetics.org
www.plosgenetics.org
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7.4999 0 0 6.6659 267.5338 230.4566 cm
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[()]TJ
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Q
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h
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46.0346 685.6441 l
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150.9165 674.6457 m
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36 652.6488 m
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2.0296 0 Td
(wild-type)Tj
3.9912 0 Td
(TDP-43)Tj
3.4299 0 Td
([)Tj
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(57)Tj
0 g
(])Tj
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1.0148 0 Td
[()63()13()]TJ
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(familial)Tj
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([)Tj
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(8)Tj
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(neuroprotective)Tj
6.582 0 Td
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1.0375 0 Td
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(cytosolic)Tj
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(of)Tj
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(restores)Tj
3.3335 0 Td
(degradation)Tj
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(even)Tj
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(in)Tj
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(the)Tj
1.474 0 Td
(presence)Tj
3.7134 0 Td
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(excess)Tj
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(TDP-43.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 247.9748 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
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/F0 1 Tf
0 -1.4976 Td
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7.1433 0 Td
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1.0488 0 Td
(TDP-43)Tj
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(causes)Tj
3.3544 0 Td
(altered)Tj
3.2362 0 Td
(cell)Tj
1.6961 0 Td
(morphology)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 212.9952 cm
BT
/F8 1 Tf
1 TL
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4.0024 0 Td
(overexpressed)Tj
5.8507 0 Td
(polyQ)Tj
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[()14(\r)]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 219.1181 204.4346 cm
BT
/F8 1 Tf
1 TL
-0.0053 Tc
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(+)Tj
ET
Q
q
1 j
1 J
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BT
/F8 1 Tf
1 TL
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(35)Tj
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(so)Tj
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[()14(\r)]TJ
ET
Q
q
1 j
1 J
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7.4999 0 0 6.6659 454.9606 204.4346 cm
BT
/F8 1 Tf
1 TL
-0.0053 Tc
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(+)Tj
ET
Q
q
1 j
1 J
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BT
/F8 1 Tf
1 TL
-0.004 Tc
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(])Tj
0.5612 0 Td
(and)Tj
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([)Tj
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[()11()12( )]TJ
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Q
q
1 j
1 J
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7.4999 0 0 6.6659 498.274 204.4346 cm
BT
/F8 1 Tf
1 TL
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Q
q
1 j
1 J
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BT
/F8 1 Tf
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(])Tj
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(,)Tj
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(60)Tj
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(].)Tj
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(inhibited)Tj
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(growth)Tj
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([)Tj
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[()14(\r)]TJ
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Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 499.2377 191.4519 cm
BT
/F8 1 Tf
1 TL
-0.0053 Tc
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(+)Tj
ET
Q
q
1 j
1 J
0 w
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BT
/F8 1 Tf
1 TL
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(])Tj
0.5612 0 Td
(and)Tj
1.7291 0 Td
([)Tj
/F12 1 Tf
[()11()12( )]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 542.6078 191.4519 cm
BT
/F8 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(-)Tj
ET
Q
q
1 j
1 J
0 w
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BT
/F8 1 Tf
1 TL
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(])Tj
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(cells)Tj
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(in)Tj
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[()14(\r)]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 463.4645 165.4299 cm
BT
/F8 1 Tf
1 TL
-0.0053 Tc
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(+)Tj
ET
Q
q
1 j
1 J
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BT
/F8 1 Tf
1 TL
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(])Tj
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([)Tj
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[()11()12( )]TJ
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Q
q
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1 J
0 w
7.4999 0 0 6.6659 536.9385 165.4299 cm
BT
/F8 1 Tf
1 TL
-0.0053 Tc
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(-)Tj
ET
Q
q
1 j
1 J
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BT
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([)Tj
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[()14(\r)]TJ
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Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 382.1669 126.4251 cm
BT
/F8 1 Tf
1 TL
-0.0053 Tc
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ET
Q
q
1 j
1 J
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BT
/F8 1 Tf
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(this)Tj
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(\).)Tj
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(74D-694)Tj
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[()14(\r)]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 219.1181 100.4598 cm
BT
/F8 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(+)Tj
ET
Q
q
1 j
1 J
0 w
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BT
/F8 1 Tf
1 TL
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(in)Tj
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([)Tj
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[()11()12( )]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 253.8708 87.4204 cm
BT
/F8 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(-)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 256.4787 82.9984 cm
BT
/F8 1 Tf
1 TL
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(])Tj
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(W303)Tj
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ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 133.6819 23.6976 re
W* n
q
133.6252 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 450.4818 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Sis1)Tj
2.133 0 Td
(Chapero)Tj
3.7631 0 Td
(ne)Tj
1.311 0 Td
(and)Tj
1.8567 0 Td
(TDP-43)Tj
3.6213 0 Td
(toxicity)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
95.5276 34.9228 m
251.8299 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
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