3D printing for the development of in vitro cancer models

Samavedi, S and Joy, Nikhita (2017) 3D printing for the development of in vitro cancer models. Current Opinion in Biomedical Engineering. ISSN 2468-4511 (In Press)

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Abstract

In vitro engineering of tumor milieus is complex because cancer progression and metastasis involve spatio-temporally evolving cell-matrix interactions, myriad interactions between tumor cells and auxiliary cells, hypoxic cores, leaky unorganized vasculature and a host of signaling molecules. Recent advances in 3D printing approaches enable the precise placement of cells, bioactive factors and biomaterials, thus permitting the recapitulation of several features associated with the in vivo tumor microenvironment. 3D printed in vitro tumor models can serve as robust platforms to study mechanisms of disease progression, enable high throughput screening of drugs and aid the development of next generation molecular therapies. This focused review discusses the importance and relevance of 3D printing technologies in building 3D tumor models in vitro. Several recent 3D printed cancer models are discussed, as also the evolution and features of next-generation models.

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IITH Creators:
IITH CreatorsORCiD
Samavedi, SUNSPECIFIED
Item Type: Article
Uncontrolled Keywords: 3D printing; Bioprinting; In vitro model; Cancer; Tumor microenvironment; Drug testing
Subjects: Chemical Engineering
Divisions: Department of Chemical Engineering
Depositing User: Team Library
Date Deposited: 20 Jun 2017 10:49
Last Modified: 20 Jun 2017 10:49
URI: http://raiith.iith.ac.in/id/eprint/3275
Publisher URL: https://doi.org/10.1016/j.cobme.2017.06.003
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