Sustained drug release from multi-layered sequentially crosslinked electrospun gelatin nanofiber mesh

Laha, A and Sharma, Chandra Shekhar and Majumdar, Saptarshi (2017) Sustained drug release from multi-layered sequentially crosslinked electrospun gelatin nanofiber mesh. Materials Science and Engineering: C, 76. pp. 782-786. ISSN 0928-4931 (In Press)

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Abstract

The aim of this study is to develop electrospun gelatin nanofibers based drug delivery carrier to achieve controlled and sustainable release of hydrophobic drug (piperine) for prolonged time. To accomplish this, we devised some strategies such as sandwiching the drug loaded gelatin nanofiber mesh with another gelatin nanofiber matrix without drug (acting as diffusion barrier), sequential crosslinking and finally, a combination of both. As fabricated multilayered electrospun nanofibers mesh was first characterized in terms of degradation study, morphology, drug-polymer interactions, thermal stability followed by studying their release kinetics in different physiological pH as per the gastrointestinal tract. Our results show that with optimized diffusional barrier support and sequential crosslinking together, a zero order sustained drug release up to 48 h may be achieved with a flexibility to vary the drug loading as per the therapeutic requirements. This work lays out the possibility of systematic design of multilayer nano-fiber mesh of a biopolymer as a drug delivery vehicle for hydrophobic drugs with a desired signature of zero order release for prolonged duration.

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IITH Creators:
IITH CreatorsORCiD
Sharma, Chandra ShekharUNSPECIFIED
Majumdar, SaptarshiUNSPECIFIED
Item Type: Article
Additional Information: The authors acknowledge to Indian Institute of Technology Hyderabad for providing necessary research infrastructure to carry out this work. Authors also acknowledge DST Nano-Mission (Dept. of Science and Technology, Nano-Mission Committee, Govt. of India; Reference No. - SR/NM/NS-1006/2016) for approving the funding to this research work.
Uncontrolled Keywords: Gelatin nanofiber; Hydrophobic drug; Zero order release; Crosslinking; Multi-layers
Subjects: Chemical Engineering > Biochemical Engineering
Divisions: Department of Chemical Engineering
Depositing User: Team Library
Date Deposited: 21 Mar 2017 10:12
Last Modified: 17 Oct 2017 09:51
URI: http://raiith.iith.ac.in/id/eprint/3106
Publisher URL: https://doi.org/10.1016/j.msec.2017.03.110
OA policy: http://www.sherpa.ac.uk/romeo/issn/0928-4931/
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