Non-heme dioxygenases in tumor hypoxia: They're all bound with the same fate

Roy, Anindya (2017) Non-heme dioxygenases in tumor hypoxia: They're all bound with the same fate. DNA Repair, 49. pp. 21-25. ISSN 1568-7864

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Abstract

Tumor tissues are known to harbor hypoxic areas. The hypoxic microenvironment promotes angiogenesis. Hypoxic tumor cells also manifest genome instability. DNA damage repair pathways, such as double-strand break repair, mismatch repair and base excision repair are known to be altered during hypoxia. This review is focused on the non-heme Fe(II) and 2-oxoglutarate-dependent dioxygenases which are involved in repair of DNA alkylation adducts. Activities of these DNA repair enzymes are completely oxygen-dependent and little information is available about inhibition of these enzymes during hypoxia. While impairment of function of non-heme dioxygenase during tumor hypoxia has been implicated in different studies, the possible outcomes with respect to mutagenesis and genomic instability are explored here.

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IITH Creators:
IITH CreatorsORCiD
Roy, Anindyahttp://orcid.org/0000-0001-8561-907X
Item Type: Article
Uncontrolled Keywords: Fe(II)/2-oxoglutarate-dependent dioxygenase; Non-heme dioxygenase; Hypoxia; Cancer; Tumor; DNA repair; 1meA; 3meC; AlkB; ALKBH2; ALKBH3
Subjects: Others > Biotechnology
Divisions: Department of Biotechnology
Depositing User: Team Library
Date Deposited: 08 Mar 2017 09:29
Last Modified: 05 Dec 2017 04:49
URI: http://raiith.iith.ac.in/id/eprint/3073
Publisher URL: https://doi.org/10.10165/j.dnarep.2016.12.001
OA policy: http://www.sherpa.ac.uk/romeo/issn/1568-7864/
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