Ultrasensitive, Label Free, Chemiresistive Nanobiosensor Using Multiwalled Carbon Nanotubes Embedded Electrospun SU-8 Nanofibers

Durga Prakash, M and Vanjari, Siva Rama Krishna and Sharma, C S and Singh, Shiv Govind (2016) Ultrasensitive, Label Free, Chemiresistive Nanobiosensor Using Multiwalled Carbon Nanotubes Embedded Electrospun SU-8 Nanofibers. Sensors, 16 (9). p. 1354. ISSN 1424-8220

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Abstract

This paper reports the synthesis and fabrication of aligned electrospun nanofibers derived out of multiwalled carbon nanotubes (MWCNTs) embedded SU-8 photoresist, which are targeted towards ultrasensitive biosensor applications. The ultrasensitivity (detection in the range of fg/mL) and the specificity of these biosensors were achieved by complementing the inherent advantages of MWCNTs such as high surface to volume ratio and excellent electrical and transduction properties with the ease of surface functionalization of SU-8. The electrospinning process was optimized to precisely align nanofibers in between two electrodes of a copper microelectrode array. MWCNTs not only enhance the conductivity of SU-8 nanofibers but also act as transduction elements. In this paper, MWCNTs were embedded way beyond the percolation threshold and the optimum percentage loading of MWCNTs for maximizing the conductivity of nanofibers was figured out experimentally. As a proof of concept, the detection of myoglobin, an important biomarker for on-set of Acute Myocardial Infection (AMI) has been demonstrated by functionalizing the nanofibers with anti-myoglobin antibodies and carrying out detection using a chemiresistive method. This simple and robust device yielded a detection limit of 6 fg/mL.

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IITH Creators:
IITH CreatorsORCiD
Vanjari, Siva Rama KrishnaUNSPECIFIED
Sharma, C SUNSPECIFIED
Singh, Shiv Govindhttp://orcid.org/0000-0001-7319-879X
Item Type: Article
Uncontrolled Keywords: ultra sensitivity; nanobiosensors; electrospinning; MWCNTs; SU-8; chemiresistive
Subjects: Others > Electricity
Chemical Engineering > Biochemical Engineering
Divisions: Department of Chemical Engineering
Department of Electrical Engineering
Depositing User: Team Library
Date Deposited: 08 Sep 2016 09:45
Last Modified: 16 Jan 2019 10:30
URI: http://raiith.iith.ac.in/id/eprint/2737
Publisher URL: https://dx.doi.org/10.3390/s16091354
OA policy: http://www.sherpa.ac.uk/romeo/issn/1424-8220/
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