Electrochemical Detection of Cardiac Biomarkers Utilizing Electrospun Multiwalled Carbon Nanotubes Embedded SU-8 Nanofibers

Prakash, M Durga and Singh, Shiv Govind and Sharma, Chandra Shekhar and Vanjari, Siva Rama Krishna (2017) Electrochemical Detection of Cardiac Biomarkers Utilizing Electrospun Multiwalled Carbon Nanotubes Embedded SU-8 Nanofibers. Electroanalysis, 29 (2). pp. 380-386. ISSN 1040 0397

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Abstract

n this paper we demonstrate synthesis and characterization of MWCNTs embedded SU-8 electrospun nanofibers and their application towards ultrasensitive detection of cardiac biomarkers using Electrochemical Impedance spectroscopy (EIS). The composite nanofibers have excellent electrical and transduction properties owing to the presence of MWCNTs in addition to ease of functionalization and biocompatibility, which can be attributed to the presence of SU-8. Thus the synthesized nanofibers are ideal candidates for sensitive biosensor applications. As a proof concept, the detection of cardiac biomarkers, Myoglobin (Myo), cardiac Troponin I (cTn I) and Creatine Kinase MB (CK-MB) is demonstrated. The synthesized nanofibers were functionalized with the antibodies of the biomarkers and the detection was carried using Electrochemical Impedance Spectroscopy, an excellent technique for understanding the adsorption kinetics. A minimum detection limit of nano-gram/ml is demonstrated using this nanobiosensor platform.

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IITH Creators:
IITH CreatorsORCiD
Singh, Shiv Govindhttp://orcid.org/0000-0001-7319-879X
Sharma, Chandra ShekharUNSPECIFIED
Vanjari, Siva Rama KrishnaUNSPECIFIED
Item Type: Article
Uncontrolled Keywords: Electrospinning;Nanofiber;Electrochemical Impedance Spectroscopy;MWCNT;SU-8;Cardiac Biomarkers
Subjects: Others > Electricity
Chemical Engineering > Biochemical Engineering
Divisions: Department of Chemical Engineering
Department of Electrical Engineering
Depositing User: Team Library
Date Deposited: 17 Aug 2016 05:51
Last Modified: 22 Jan 2019 04:05
URI: http://raiith.iith.ac.in/id/eprint/2643
Publisher URL: https://doi.org/10.1002/elan.201501163
OA policy: http://www.sherpa.ac.uk/romeo/issn/1040-0397/
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