A Facile Synthesis of Chiral β-substituted α-Amino Ester Analogue of Indenone via Addition Elimination Reaction

Shiraj, Abdul and Khan, Faiz Ahmed (2016) A Facile Synthesis of Chiral β-substituted α-Amino Ester Analogue of Indenone via Addition Elimination Reaction. Masters thesis, Indian Institute of Technology Hyderabad.

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Abstract

Indenone core is a very important pharmacophore in organic chemistry. α‚ β substituted chloro or bromo indenones easily undergo addition-elimination reaction with suitable nucleophile like α-amino esters and produce the corresponding chiral β substituted α -amino ester analogue of indenone in an impressive yield. The reaction can be performed in a mild condition without any catalyst‚ base or acid. Thus formation of C-N bond is possible in this type of reaction in a catalyst free mild condition.

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IITH Creators:
IITH CreatorsORCiD
Khan, Faiz AhmedUNSPECIFIED
Item Type: Thesis (Masters)
Uncontrolled Keywords: Pharmacophore, chiral pool, TD545
Subjects: Chemistry
Divisions: Department of Chemistry
Depositing User: Library Staff
Date Deposited: 24 Jun 2016 05:58
Last Modified: 22 May 2019 05:12
URI: http://raiith.iith.ac.in/id/eprint/2475
Publisher URL:
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