Transition-Metal-Free Direct C(sp3)-H Functionalization leading to Aza-γ-Carboline Alkaloid Analogues in Cascade Fashion

Ghosh, Ruma and D S, Sharada (2016) Transition-Metal-Free Direct C(sp3)-H Functionalization leading to Aza-γ-Carboline Alkaloid Analogues in Cascade Fashion. Masters thesis, Indian Institute of Technology Hyderabad.

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Abstract

Iodine promoted cascade reaction has been developed for the synthesis of unrivalled Aza-γ-carboline alkaloid analogues via C-H functionalization of 2H-indazoles. The construction of the product has been realized under metal-free condition via in situ formation of imine, transimination followed by cyclization. In this present method iodine played a triple role, in imine formation, transimination and imine activation. The key features of the present protocol are metal-free, peroxide-free, operational simplicity and wide substrates scope.

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IITH Creators:
IITH CreatorsORCiD
D S, SharadaUNSPECIFIED
Item Type: Thesis (Masters)
Uncontrolled Keywords: Transition-metal free, Evironmentally friendly, Molecular iodine, TD503
Subjects: Chemistry
Divisions: Department of Chemistry
Depositing User: Library Staff
Date Deposited: 05 May 2016 05:07
Last Modified: 22 May 2019 10:38
URI: http://raiith.iith.ac.in/id/eprint/2316
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