Optimum culture medium composition for lipopeptide production by Bacillus subtilis using response surface model-based ant colony optimization

Jujjavarapu, S E and Mohan, Anand and C, Venkateswarlu (2016) Optimum culture medium composition for lipopeptide production by Bacillus subtilis using response surface model-based ant colony optimization. Sadhana, 41 (1). pp. 55-65. ISSN 0256-2499

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Abstract

Central composite rotatable design (CCRD) of experiments was used to obtain data for Lipopeptide and Biomass concentrations from fermentation medium containing the following five components: glucose, monosodium glutamate, yeast extract, MgSO4⋅7H2O, and K2HPO4. Data was used to develop a second order regression response surface model (RSM) which was coupled with ant colony optimization (ACO) to optimize the media compositions so as to enhance the productivity of lipopeptide. The optimized media by ACO was found to yield 1.501 g/L of lipopeptide concentration which was much higher compared to 1.387 g/L predicted by Nelder–Mead optimization (NMO). The optimum from ACO was validated experimentally. RSM-based ACO is thus shown to be an effective tool for medium optimization of biosurfactant production.

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IITH Creators:
IITH CreatorsORCiD
Mohan, Anandhttps://orcid.org/0000-0001-7191-4991
Item Type: Article
Uncontrolled Keywords: Ant colony optimization, Bacillus subtilis, central composite rotatable design, lipopeptide, response surface methodology
Subjects: Chemical Engineering > Biochemical Engineering
Divisions: Department of Chemical Engineering
Depositing User: Team Library
Date Deposited: 25 Feb 2016 10:44
Last Modified: 05 Dec 2017 05:30
URI: http://raiith.iith.ac.in/id/eprint/2218
Publisher URL: http://dx.doi.org/10.1007/s12046-015-0451-x
OA policy: http://www.sherpa.ac.uk/romeo/issn/0256-2499/
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