Sodium Alginate and Gelatin Hydrogels: Viscosity Effect on Hydrophobic Drug Release

Bhutani, A and Laha, A and Mitra, Kishalay and Majumdar, Saptarshi (2016) Sodium Alginate and Gelatin Hydrogels: Viscosity Effect on Hydrophobic Drug Release. Materials Letters, 164. pp. 76-79. ISSN 0167-577X

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Abstract

Blend of biodegradable hydrogels like sodium alginate/gelatin (SA/G) usually requires use of chemical cross-linkers to remain stable in aqueous media for drug delivery applications. This study targets the feasibility of having an entire spectrum of a model hydrophobic drug (piperine) release i.e. from burst to controlled release, by varying polymer viscosity and molecular weight of plasticizer with minimal use of cross-linkers. Swelling study, drug-polymer interactions and morphology analysis reveal the impact of viscosity variation on polymer matrix.

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IITH Creators:
IITH CreatorsORCiD
Mitra, Kishalayhttp://orcid.org/0000-0001-5660-6878
Majumdar, SaptarshiUNSPECIFIED
Item Type: Article
Additional Information: The authors acknowledge the support of Indian Institute of Technology Hyderabad, for the research facilities.
Uncontrolled Keywords: Sodium Alginate; Gelatin; Piperine; Hydrogels; Viscosity; Plasticizer
Subjects: Chemical Engineering > Biochemical Engineering
Divisions: Department of Chemical Engineering
Depositing User: Team Library
Date Deposited: 02 Nov 2015 07:32
Last Modified: 17 Oct 2017 09:54
URI: http://raiith.iith.ac.in/id/eprint/2002
Publisher URL: https://doi.org/10.1016/j.matlet.2015.10.114
OA policy: http://www.sherpa.ac.uk/romeo/issn/0167-577X/
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