One-Pot Palladium-Catalyzed Ligand- and Metal-Oxidant-Free Aerobic Oxidative Isocyanide Insertion Leading to 2-Amino-substituted-4(3H)-quinazolinones

Shinde, V and N C, Chaitra and A, Sagar and D S, Sharada (2015) One-Pot Palladium-Catalyzed Ligand- and Metal-Oxidant-Free Aerobic Oxidative Isocyanide Insertion Leading to 2-Amino-substituted-4(3H)-quinazolinones. Synthetic Communications, 45 (7). pp. 898-907. ISSN 0039-7911 (In Press)

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Abstract

An efficient, ligand- and metal-oxidant-free, one-pot, cascade aerobic oxidative, palladium-catalyzed, multicomponent reaction has been developed through isocyanide insertion of less active secondary amide and aromatic amine, which leads to 2-amino-substituted-4(3H)-quinazolinones. This approach proves to be one of the simplest methods for the synthesis of this class of valuable bioactive heterocyclic scaffolds.

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IITH Creators:
IITH CreatorsORCiD
D S, SharadaUNSPECIFIED
Item Type: Article
Uncontrolled Keywords: 2-Amino-substituted-4(3H)-quinazolinones; isocyanide insertion; Pd-catalyzed aerobic oxidation
Subjects: ?? sub5.8 ??
Divisions: Department of Chemistry
Depositing User: Team Library
Date Deposited: 18 Feb 2015 07:37
Last Modified: 06 Jan 2016 08:53
URI: http://raiith.iith.ac.in/id/eprint/1339
Publisher URL: http://dx.doi.org/10.1080/00397911.2014.992076
OA policy: http://www.sherpa.ac.uk/romeo/issn/0039-7911/
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