Palladium-catalyzed selective α-arylation of ortho -bromoacetophenones

J, Krishna and A, Gopi Krishna Reddy and G, Satyanarayana (2014) Palladium-catalyzed selective α-arylation of ortho -bromoacetophenones. Synthetic Communications, 44 (14). pp. 2103-2111. ISSN 0039-7911

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Synthesis of 1-(2-bromophenyl)-2-phenylethanones via an intermolecular Pd-catalyzed α-arylation of 1-(2-bromophenyl)ethanones is presented. The method relies on selective C-H activation (α-arylation) of relatively more reactive external iodo-arenes as coupling partners without affecting the bromo-substituent. Moreover, the scope and generality of the method has been well studied by employing the reaction with iodo-arenes as coupling partners bearing electron-withdrawing, simple, and electron-donating groups on the aromatic ring.

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IITH Creators:
IITH CreatorsORCiD
G, SatyanarayanaUNSPECIFIED
Item Type: Article
Uncontrolled Keywords: 1-(2-bromophenyl)ethanones; C-H activation; iodo-arenes; Pd-catalysis; α-Arylation
Subjects: ?? sub5.8 ??
Divisions: Department of Chemistry
Depositing User: Team Library
Date Deposited: 02 Dec 2014 09:31
Last Modified: 24 Sep 2015 10:23
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